Increasing Car T Cells To Stable Tumors?
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Although there are essential differences between these therapies, all of them share related elements. The CAR on the cell’s surface is composed of fragments, or domains, of artificial antibodies. The domains which might be used can affect how well the receptor recognizes or binds to the antigen on the tumor cell. Once the collected T cells have been engineered to express the antigen-specific CAR, they’re “expanded” within the laboratory into the hundreds of tens of millions. These particular receptors permit the T cells to recognize and attach to a selected protein, or antigen, on tumor cells.
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The CAR T cell therapies furthest along in development target an antigen found on B cells called CD19 (see the box beneath, titled “The Making of a CAR T Cell”). Dr. June has led a series of CAR T cell scientific trials, largely in sufferers with leukemia.
The company approving a new remedy in children before adults “is … Read More